Oportunidad para solicitar:
Postdoctoral Position in Cancer Drug Resistance and Intratumor
Heterogeneity
Rouen, France
A three-year postdoctoral
position funded by the French National Cancer Institute (INCa) is available in
the group of Dr. Luca Grumolato at the University of Rouen Normandie, Inserm
U1239 (Rouen, France), to investigate non-small cell lung cancer (NSCLC) resistance
to EGFR inhibitors (EGFRi). We have recently devised CRISPR-barcoding, a novel
approach to recapitulate and trace the emergence of a new mutation in a subset
of cancer cells, which enables functional studies on a gene of interest in a
context that mimics intratumor heterogeneity (Guernet et al., Mol. Cell 2016). Using
this strategy, we have identified a small molecule capable of preventing amplification
of resistant clones in the presence of EGFRi through a novel mechanism. The
aims of this project are: (1) further characterize the effects of the
identified compound, both in vitro
and in vivo, (2) investigate the
contribution of intratumor heterogeneity to NSCLC drug resistance and (3)
devise new combination treatments to eradicate resistant cells.
Inserm U1239 is a highly dynamic laboratory, which recently moved into
a new building with access to state-of-the-art imaging, proteomic and animal
facilities. Dr. Grumolato's group is supported by different National and
Regional funding agencies and associations, including INCa, ANR, Ligue contre
le Cancer and Fondation ARC. For this project, we have established a consortium
with Pr. S.A. Aaronson at the Icahn School of Medicine at Mount Sinai, New York
(USA), and Pr. A. Cortot at Lille University Hospital, UMR8161, Institute of
Biology of Lille (IBL), Lille (France).
REQUIREMENTS:
-
Ph.D. in Life Science
-
Highly motivated, hardworking
and independent
-
Strong background in cancer
biology and cell signaling
-
Solid publication record
-
Experience in molecular biology
and xenograft models is a plus
To apply, please send a brief statement of
research experience and career goals, C.V. and two reference letters to luca.grumolato@univ-rouen.fr
Application deadline: October 30th
2017
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